Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 2-(Tert-butyldiphenylsilyloxymethyl)imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 반응물 | 1H-Imidazole-2-methanol | HCID 566830 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(Tert-butyldiphenylsilyloxymethyl)imidazole | HCID 53676658 | 82% |
반응 단계
A solution of 2-hydroxymethylimidazole (1.96 g ; 0.02 mole), imidazole (3.4 g; 0.05 mole), tert-butyldiphenylsilyl chloride (6.6 g; 0.024 mole) in DMF (20 ml) was stirred under an argon atmosphere for 16 hours. The mixture was extracted with ethyl acetate and purified by flash column chromatography eluting with a gradient 50-70% ethyl acetate/petroleum ether to give 2-(tert-butyldiphenylsilyloxymethyl)imidazole as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06342765B1 |
| 출처 데이터셋 | uspto-grants-2002_01 |
| ORD ID | ord-629180fcd2854c04ab9ada2162252392 |
| 출처 메모 | uspto-grants-2002_01 |