Dimethylformamide → 2-Propionylamino-4-chloromethylthiazole

HRID 1252050노트

반응식

HRID 1252050 반응식
Cl.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([CH2:8][Cl:9])[N:7]=1.CN(C)C=O.[C:15](Cl)(=[O:18])[CH2:16][CH3:17]>N1C=CC=CC=1>[C:15]([NH:2][C:3]1[S:4][CH:5]=[C:6]([CH2:8][Cl:9])[N:7]=1)(=[O:18])[CH2:16][CH3:17]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 62324Propionyl chlorideHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)

생성물 1

HCID 103980162-Propionylamino-4-chloromethylthiazole수율 50.9%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a mixture of 2-amino-4-chloromethylthiazole hydrochloride (50 g), anhydrous N,N-dimethylformamide (250 ml) and anhydrous pyridine (50 ml) was added dropwise propionyl chloride (30 g) keeping the temperature below 3° C. with stirring and the mixture was stirred for 20 minutes at the same temperature. The reaction mixture was poured into ice water (1500 ml) and stirred. The crystal was collected by filtration and washed with water to give 2-propionylamino-4-chloromethylthiazole (28.15 g).

후처리

  1. customthe temperature below 3° C.
  2. stirringthe mixture was stirred for 20 minutes at the same temperature
  3. stirringstirred
  4. filtrationThe crystal was collected by filtration
  5. washwashed with water

출처 및 근거

ORD 기록
ord-8e8a672ea0f1401db3ffc3191c2a785e
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04742057

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