Sodium Sulfite → 4-p-Methoxybenzyloxycarbonyl-4-methylvaleric acid

HRID 1252218노트

반응식

HRID 1252218 반응식
S([O-])([O-])=O.[Na+].[Na+].[CH3:7][O:8][C:9]1[CH:36]=[CH:35][C:12]([CH2:13][O:14][C:15]([C:17]([CH3:34])([CH3:33])[CH2:18][CH2:19][C:20]([O:22]CC2C=CC([N+]([O-])=O)=CC=2)=[O:21])=[O:16])=[CH:11][CH:10]=1>O.O1CCCC1>[CH3:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][O:14][C:15]([C:17]([CH3:33])([CH3:34])[CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[O:16])=[CH:35][CH:36]=1

참가 물질

5

반응물 2

HCID 24437Sodium SulfiteHCID 20140840p-Nitrobenzyl 4-p-methoxybenzyloxycarbonyl-4-methylvalerate

생성물 1

HCID 141557204-p-Methoxybenzyloxycarbonyl-4-methylvaleric acid

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of sodium sulfite hydrade (12.35 g) in water (70 ml) was added a solution of p-nitrobenzyl 4-p-methoxybenzyloxycarbonyl-4-methylvalerate (25.4 g) in tetrahydrofuran (140 ml). The reaction mixture was stirred at room temperature for 7.5 hours, diluted with water and washed with diethyl ether. The aqueous layer was acidified with hydrochloric acid and extracted with diethyl ether. The extract was washed with water, dried over anhydrous sodium sulfate and evaporated to give 4-p-methoxybenzyloxycarbonyl-4-methylvaleric acid.

후처리

  1. washwashed with diethyl ether
  2. extractionextracted with diethyl ether
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-78dd7377fb6a46e2813f08950e124011
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04742052

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