Ethylamine → Ethyl N-ethyl-beta-alaninate

HRID 1252277

반응식

HRID 1252277 반응식
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH2:8]([NH2:10])[CH3:9]>C(O)C>[CH2:8]([NH:10][CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])[CH3:9]

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 8821Ethyl Acrylate

생성물 1

HCID 90223Ethyl N-ethyl-beta-alaninate수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

50 g (0.50 mole) of ethyl acrylate was dissolved in 500 ml of ethanol. To the resulting solution being stirred in an ice bath was added dropwise a mixed solution consisting of 36 g of a 70% aqueous ethylamine solution (containing 0.55 mole of ethylamine) and 100 ml of ethanol, in 3.5 hours. The reaction was continued for further 3 hours and then the solvent was distilled off. The resulting residue was subjected to vacuum distillation to obtain 50.5 g of a desired product with an yield of 70%.

후처리

  1. additionwas added dropwise a mixed solution
  2. distillationthe solvent was distilled off
  3. distillationThe resulting residue was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-492d6bc4bbf641baa72369207291587a
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04742165

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