2-Bromopropanoyl chloride → HCID 15611036, 화합물

HRID 1252338

반응식

HRID 1252338 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11]([NH2:14])(=[O:13])=[O:12].[Br:15][CH:16]([CH3:20])[C:17](Cl)=[O:18]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11]([NH:14][C:17](=[O:18])[CH:16]([Br:15])[CH3:20])(=[O:13])=[O:12]

참가 물질

3

반응물 2

HCID 979802-Bromopropanoyl chlorideHCID 209044Benzenesulfonamide, 2,5-dimethoxy-

생성물 1

HCID 15611036HCID 15611036, 화합물

실험 절차

A stirred mixture of 7.0 g (0.032 mole) of 2,5-dimethoxyphenylsulfonamide in 10 mL of 2-bromopropionyl chloride was heated at reflux for 40 minutes then allowed to cool to room temperature. The resultant solution was poured into petroleum ether. Crystals formed after scratching the sides of the flask and were collected by filtration. The filter cake was washed four times with fresh petroleum ether to yield 10.3 g of N-(2,5-dimethoxyphenylsulfonyl)-2-bromopropionamide (mp 116°-118° C.).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 40 minutes
  3. customCrystals formed
  4. filtrationwere collected by filtration
  5. washThe filter cake was washed four times with fresh petroleum ether

출처 및 근거

ORD 기록
ord-ad1850dfc57645cea693789b1dbf4e04
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04743291

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