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Potassium Carbonate → N-(2,3-dihydro-2,2-dimethylbenzofuran-5-yl)sulfonyl-2-[2-chloro-4-fluoro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)phenoxy]propionamide

HRID 1252347
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HRID 1252347 반응식
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:13](=[O:14])[N:12]([CH:15]([F:17])[F:16])[C:11]([CH3:18])=[N:10]2)=[C:4]([F:19])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:26][C:27]1([CH3:45])[CH2:31][C:30]2[CH:32]=[C:33]([S:36]([NH:39][C:40](=[O:44])[CH:41](Br)[CH3:42])(=[O:38])=[O:37])[CH:34]=[CH:35][C:29]=2[O:28]1>CC(C)=O>[CH3:45][C:27]1([CH3:26])[CH2:31][C:30]2[CH:32]=[C:33]([S:36]([NH:39][C:40](=[O:44])[CH:41]([O:8][C:7]3[CH:6]=[C:5]([N:9]4[C:13](=[O:14])[N:12]([CH:15]([F:16])[F:17])[C:11]([CH3:18])=[N:10]4)[C:4]([F:19])=[CH:3][C:2]=3[Cl:1])[CH3:42])(=[O:38])=[O:37])[CH:34]=[CH:35][C:29]=2[O:28]1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 137694562-(4-Chloro-2-fluoro-5-hydroxyphenyl)-4-(difluoromethyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 15611041N-(2,3-dihydro-2,2-dimethylbenzofuran-5-yl)sulfonyl-2-bromopropionamide

생성물 1

HCID 20139698N-(2,3-dihydro-2,2-dimethylbenzofuran-5-yl)sulfonyl-2-[2-chloro-4-fluoro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)phenoxy]propionamide수율 91.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In a manner similar to Step D of Example 9, the reaction of 0.5 g (0.0017 mole) of 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-one with 0.7 g (0.0051 mole) of potassium carbonate and 0.62 g (0.0017 mole) of N-(2,3-dihydro-2,2-dimethylbenzofuran-5-yl)sulfonyl-2-bromopropionamide in 35 mL of acetone produced 0.89 g of N-(2,3-dihydro-2,2-dimethylbenzofuran-5-yl)sulfonyl-2-[2-chloro-4-fluoro-5-(4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)phenoxy]propionamide as a solid.

출처 및 근거

ORD 기록
ord-3f19dabb3baa4d63b7fd21df192cc445
출처 데이터셋
uspto-grants-1988_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04743291

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