Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,7-Dichloroquinoline → 7-Chloro-N-[(1-hydroxycyclohexyl)methyl]-4-quinolinamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,7-Dichloroquinoline | HCID 6866 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1) | HCID 3084332 | — |
| 용매 | Glycol monoethyl ether | HCID 8076 | — |
| 생성물 | 7-Chloro-N-[(1-hydroxycyclohexyl)methyl]-4-quinolinamine | HCID 14209233 | 54.5% |
반응 단계
A solution of 20 g of 4,7-dichloroquinoline, 20 g of 1-aminomethyl-1-cyclohexanol hydrochloride and 3 equivalents of triethylamine in 80 ml of 2-ethoxyethanol was stirred at reflux until the reaction was complete. The reaction was complete after 16 hours, and upon dilution of the reaction mixture with water (300 ml), a solid precipitated out which was isolated by filtration. Recrystallization from ethanol gave 16 g of crystalline solid with a melting point of 205°-207° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04743601 |
| 출처 데이터셋 | uspto-grants-1988_05 |
| ORD ID | ord-cafc0f972afe4f77b65223a628870c2b |
| 출처 메모 | uspto-grants-1988_05 |