Water → HCID 14209239, 화합물

HRID 1252402노트

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HRID 1252402 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH2:13]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:4][CH2:3][CH:2]([OH:13])[CH3:11])=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

3

반응물 2

HCID 962WaterHCID 6183063-Bromo-4-chloroquinoline

생성물 1

HCID 14209239HCID 14209239, 화합물

반응 조건

온도
150 °C

실험 절차

A mixture of 3 g of 3-bromo-4-chloro-quinoline and 10 g of aminopropanol-2 was heated to 150° C. for 20 minutes. The mixture was cooled and poured into 120 ml of water and the product was extracted with 100 ml of ether. The ether layer was dried over sodium sulfate, the solvent removed by evaporation and the residue recrystallized from ether/hexane. The yield was 2.6 g, mp 82°-83° C.

후처리

  1. temperatureThe mixture was cooled
  2. extractionthe product was extracted with 100 ml of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent removed by evaporation
  5. customthe residue recrystallized from ether/hexane

출처 및 근거

ORD 기록
ord-ccca9300df774a6ba48d9a6574112126
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04743601

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