Water → HCID 14209242, 화합물

HRID 1252406노트

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HRID 1252406 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1Cl)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH:13][CH:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:15][NH2:16].O>C(OC(O)C)C>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:16][CH2:15][CH:14]([OH:13])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

5

반응물 3

HCID 962WaterHCID 1000PhenylethanolamineHCID 6183063-Bromo-4-chloroquinoline

생성물 1

HCID 14209242HCID 14209242, 화합물

시약·촉매·용매 1

HCID 101298981-Ethoxyethanol용매

실험 절차

A solution of 4 g of 3-bromo-4-chloro-quinoline and 6 g of 2-hydroxy-2-phenyl-ethylamine was heated at 150° C. for 3 hours in 10 ml of ethoxyethanol. The mixture was cooled and poured into 150 ml of water. The product was extracted with two 50 ml portions of ether. The ether layer was dried over sodium sulfate, the solvent was evaporated and the residue was recrystallized from isopropanol. The yield was 3.0 g, mp 131°-132° C.

후처리

  1. temperatureThe mixture was cooled
  2. extractionThe product was extracted with two 50 ml portions of ether
  3. dry with materialThe ether layer was dried over sodium sulfate
  4. customthe solvent was evaporated
  5. customthe residue was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-6d84c292ad194362b91031070ea5fa0c
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04743601

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