Ethyl 5,6-diphenylpyridine-2-carboxylate → Methyl 5,6-diphenylpyridine-2-carboxylate

HRID 12525

반응식

HRID 12525 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19]([O:21][CH2:22]C)=[O:20])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>OS(O)(=O)=O.CO.O>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19]([O:21][CH3:22])=[O:20])=[N:11][C:12]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 1

HCID 14789610Ethyl 5,6-diphenylpyridine-2-carboxylate2회

생성물 1

HCID 13487992Methyl 5,6-diphenylpyridine-2-carboxylate

시약·촉매·용매 3

HCID 1118Sulfuric Acid촉매HCID 887Methanol용매HCID 962Water용매

실험 절차

General Procedure E. A solution of ethyl 5,6-diphenylpyridine-2-carboxylate (Compound 21, 30 mg, 0.1 mmol) and conc. H2SO4 (3 drops) in MeOH (5 ml) was heated at 50° C. overnight. The mixture was diluted with water, and the products were extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over Na2SO4. The filtered solvent was concentrated in vacuo and the residue was purified by column chromatography (20% ethyl acetate in hexane) to obtain the title compound as a yellow solid.

후처리

  1. extractionthe products were extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over Na2SO4
  4. concentrationThe filtered solvent was concentrated in vacuo
  5. customthe residue was purified by column chromatography (20% ethyl acetate in hexane)

출처 및 근거

ORD 기록
ord-c8ed5a439c8346ba9a574f8b0447231e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728014B2

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