2-Chloroethyl isocyanate → 2-[[[[(2-Chloroethyl)amino]carbonyl]amino]methyl]-5-(phenylmethoxy)-2-(phenylmethyl)-4(1H)-pyridinone

HRID 1252606노트

반응식

HRID 1252606 반응식
[NH2:1][CH2:2][C:3]1[N:4](CC2C=CC=CC=2)[CH:5]=[C:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:7](=[O:9])[CH:8]=1.[Cl:25][CH2:26][CH2:27][N:28]=[C:29]=[O:30]>C(OCC)(=O)C>[Cl:25][CH2:26][CH2:27][NH:28][C:29]([NH:1][CH2:2][C:3]1([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][C:7](=[O:9])[C:6]([O:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][NH:4]1)=[O:30]

참가 물질

4

반응물 2

HCID 160352-Chloroethyl isocyanateHCID 120385614(1H)-Pyridinone, 2-(aminomethyl)-5-(phenylmethoxy)-1-(phenylmethyl)-

생성물 1

HCID 201403872-[[[[(2-Chloroethyl)amino]carbonyl]amino]methyl]-5-(phenylmethoxy)-2-(phenylmethyl)-4(1H)-pyridinone수율 185.7%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a suspension of 48.0 g (0.15 mol) of 2-(aminomethyl)-5-(phenylmethoxy)-1-(phenylmethyl)-4(1H)-pyridinone in 1.5 l of ethyl acetate was added 12.8 ml (0.15 mol) of 2-chloroethylisocyanate. The mixture was stirred overnight at room temperature, the product filtered off by suction, washed with ethyl acetate, and dried in vacuo, yielding 59.6 g of the title compound, melting point 130° C.

후처리

  1. filtrationthe product filtered off by suction
  2. washwashed with ethyl acetate
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-821b738d6c6d4d7d9260303e91a32432
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04743685

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