Sulfuric Acid → HCID 13090699, 화합물

HRID 1252653노트

반응식

HRID 1252653 반응식
[CH3:1][C:2](=[CH2:4])[CH3:3].[Cl:5][C:6]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:7]=1[O:8][C:9]1[CH:10]=[C:11]([C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=1)[CH2:12][OH:13].S(=O)(=O)(O)O>ClCCCl>[C:2]([O:13][CH2:12][C:11]1[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=[C:9]([O:8][C:7]2[CH:20]=[CH:21][C:22]([C:24]([F:25])([F:26])[F:27])=[CH:23][C:6]=2[Cl:5])[CH:10]=1)([CH3:3])([CH3:1])[CH3:4]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 13050461HCID 13050461, 화합물

생성물 1

HCID 13090699HCID 13090699, 화합물수율 89%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Isobutylene gas was passed into a solution of 17.4 parts by weight of 3-(2'-chloro-4'-trifluoromethylphenoxy)-6-nitrobenzyl alcohol in 100 parts by volume of 1,2-dichloroethane and 0.5 parts by weight of sulfuric acid at 40° C. for two hours. The reaction mixture was then washed with dilute aqueous sodium bicarbonate solution and twice with water, and the organic phase was dried with magnesium sulfate, filtered and concentrated. 18 parts by weight (89% of theory) of 3-(2'-chloro-4'-trifluoromethylphenoxy)-6-nitrobenzyl tert.-butyl ether (compound No. 16) of melting point 75°-78° C. were obtained.

후처리

  1. washThe reaction mixture was then washed with dilute aqueous sodium bicarbonate solution and twice with water
  2. dry with materialthe organic phase was dried with magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7c9708faba114c70802d766b663561d9
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04744812

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