Dicyclohexylcarbodiimide → HCID 178446735, 화합물

HRID 1252841노트

반응식

HRID 1252841 반응식
[C:1]1([CH2:7][O:8][C:9]([NH:11][CH:12]([PH:17](=[O:19])[OH:18])[CH2:13][CH2:14][CH2:15][CH3:16])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[C@@H:21]([CH3:39])[C:22]([N:24]1[CH2:38][CH2:37][CH2:36][C@H:25]1[C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])=[O:23].C1(N=C=NC2CCCCC2)CCCCC1.CN(C1C=CC=CN=1)C>O1CCCC1>[C:1]1([CH2:7][O:8][C:9]([NH:11][CH:12]([PH:17]([O:18][CH:21]([CH3:39])[C:22]([N:24]2[CH2:38][CH2:37][CH2:36][C@H:25]2[C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])=[O:23])=[O:19])[CH2:13][CH2:14][CH2:15][CH3:16])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 10868DicyclohexylcarbodiimideHCID 218852-DimethylaminopyridineHCID 133352881-[(S)-2-Hydroxy-1-oxopropyl]-L-proline, phenylmethyl esterHCID 178446733HCID 178446733, 화합물

생성물 1

HCID 178446735HCID 178446735, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1-[[(phenylmethoxy)carbonyl]amino]pentylphosphinic acid (490 mg., 1.72 mmole) and 1-[(S)-2-hydroxy-1-oxopropyl]-L-proline, phenylmethyl ester (255 mg., 0.92 mmole) in dry tetrahydrofuran (5 ml.) is treated with dicyclohexylcarbodiimide (285 mg., 1.38 mmole) and dimethylaminopyridine (50 mg.) and stirred at room temperature for 2.5 hours. The mixture is filtered, diluted with ethyl acetate, and washed successively with 5% potassium bisulfate, saturated sodium bicarbonate, and saturated sodium chloride solutions, dried over sodium sulfate, and evaporated to give crude (S)-1-[2-[[[1-[[(phenylmethoxy)carbonyl]amino]pentyl]phosphinyl]oxy]-1-oxopropyl]-L-proline, phenylmethyl ester.

후처리

  1. filtrationThe mixture is filtered
  2. additiondiluted with ethyl acetate
  3. washwashed successively with 5% potassium bisulfate, saturated sodium bicarbonate, and saturated sodium chloride solutions
  4. dry with materialdried over sodium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-2232f2c2c60d4618b5cdcd7f3c5f988b
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04745196

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