Tetrahydrofuran → 4-Acetylthiomethyl-1,2,3-thiadiazole

온도

23 °C

To a solution of 1,2,3-thiadiazol-4-ylmethanol methanesulfonate (0.90 g, 4.6 mmol) in tetrahydrofuran (9 mL) was added an aqueous solution (2 mL) of sodium thiolacetate [prepared from thiolacetic acid (0.38 mL, 5.3 mmol) and sodium bicarbonate (0.445 g, 5.3 mmol)]. The resulting mixture was stirred at 23° C. for 1 h and diluted with ether (75 mL). The organic solution was washed with water (3×3 mL), dried (MgSO4) and concentrated. The crude mixture was purified by chromatography (silica gel column: 1.4×19 cm) with 50% ether in hexane as eluting solvent to give 0.60 g (75%);

1. washThe organic solution was washed with water (3×3 mL)
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. customThe crude mixture was purified by chromatography (silica gel column: 1.4×19 cm) with 50% ether in hexane
5. washas eluting solvent
6. customto give 0.60 g (75%)

ORD 기록

ord-c15658dc0d6640a38043aece635bc8ab

출처 데이터셋

uspto-grants-1988_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04746736