2-Amino-4,6-dimethoxypyrimidine → 4-(Cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-methyl-1H-pyrazole-5-sulfonamide

HRID 1253137노트

반응식

HRID 1253137 반응식
[CH:1]1([C:4]([C:6]2[CH:7]=[N:8][N:9]([CH3:15])[C:10]=2[S:11]([NH2:14])(=[O:13])=[O:12])=[O:5])[CH2:3][CH2:2]1.C1(N[C:23](=O)[O-:24])C=CC=CC=1.[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[N:31]=[C:30]([NH2:36])[N:29]=1.[N+](=C1CCCCCCCCCC1C1CCCCCCCCCC1)=[N-]>C(#N)C>[CH:1]1([C:4]([C:6]2[CH:7]=[N:8][N:9]([CH3:15])[C:10]=2[S:11]([NH:14][C:23]([NH:36][C:30]2[N:31]=[C:32]([O:34][CH3:35])[CH:33]=[C:28]([O:27][CH3:26])[N:29]=2)=[O:24])(=[O:13])=[O:12])=[O:5])[CH2:2][CH2:3]1

참가 물질

6

반응물 4

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 142309984-Cyclopropylcarbonyl-1-methyl-5-pyrazolesulfonamideHCID 21896570PhenylcarbamateHCID 22171225HCID 22171225, 화합물

생성물 1

HCID 142309994-(Cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-methyl-1H-pyrazole-5-sulfonamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a stirring mixture of the sulfonamide from Example 2 (175 mg, 0.76 mmol) and the phenylcarbamate of 4,6-dimethoxy-2-aminopyrimidine (210 mg, 0.76 mmol) in 3ml of acetonitrile was added diazobicycloundecane (116 mg, 0.76 mmol). The solution was stirred for approximately 10 minutes. Acidification of the reaction mixture and filtration of the resulting solids afforded 300 mg of the desired compound m.p. 189°-192° C. NMR (200 MHz, CDCl3) 1.0 (m, 2H), 1.1 (m, 2H), 2.4 (m, 1H), 4.0 (s, 6H), 4.35 (s, 1H), 5.80 (s, 1H), 7.4 (br. s, 1H), 8.05 (s, 1H), 12.9 (s, 1H).

후처리

  1. filtrationAcidification of the reaction mixture and filtration of the resulting solids

출처 및 근거

ORD 기록
ord-f761c60319374e4c9f87c57163d94478
출처 데이터셋
uspto-grants-1988_05
특허 번호
US04747870

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