Ammonia → HCID 20137145, 화합물
반응식
[CH2:1]([NH:3][C:4](=S)[NH:5][C:6]1[CH:10]=[N:9][N:8]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]#[N:16])[N:7]=1)[CH3:2].[NH3:18]>>[CH2:1]([N:3]=[C:4]([NH2:18])[NH:5][C:6]1[CH:10]=[N:9][N:8]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]#[N:16])[N:7]=1)[CH3:2]참가 물질
3
실험 절차
A solution of 5-[4-(3-ethylthioureido)-1,2,3-triazol-2-yl]valeronitrile (2.2 g.) in methanolic ammonia (6M; 20 ml.) was treated with yellow mercuric oxide (2.08 g.) and the resulting suspension stirred at room temperature for 18 hours. The suspension was filtered through diatomaceous earth and the filtrate evaporated to give an oil which was purified by medium pressure chromatography using EtOAc then MeOH/EtOAc 1:1 v/v as eluants to give 5-[4-[2-ethylguanidino)-1,2,3-triazol-2-yl]valeronitrile (1.35 g.).
후처리
- filtrationThe suspension was filtered through diatomaceous earth
- customthe filtrate evaporated
- customto give an oil which
- customwas purified by medium pressure chromatography
출처 및 근거
- ORD 기록
- ord-4e2bb491e7374d388a05d900d3718204
- 출처 데이터셋
- uspto-grants-1988_05
- 특허 번호
- US04748165
반응 노트
불러오는 중…