Trifluoroacetic acid → Methyl (R)-3-(methylamino)-2,3-dihydro-1H-indene-5-carboxylate
반응식
C(O)(C(F)(F)F)=O.C(O[C:13]([N:15](C)[C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1)=O)(C)(C)C>C(Cl)Cl>[CH3:13][NH:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1참가 물질
4
실험 절차
TFA (2 ml) was added dropwise to a solution of (R)-methyl 3-(tert-butoxycarbonyl(methyl)-amino)-2,3-dihydro-1H-indene-5-carboxylate (760 mg, 2.49 mmol, 1.0 eq.) in methylene chloride (10 ml) at 0° C. The reaction mixture was then stirred at RT for 2 h. After completion of the reaction, the reaction mixture was concentrated to afford the desired product which was used in the next step without further purification.
후처리
- customAfter completion of the reaction
- concentrationthe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-68b04f90a77c4ff4877b6b8d38399022
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08455475B2
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