Trifluoroacetic acid → 8-(4-Fluorophenyl)-2,8-diazaspiro[4.5]decane

HRID 1253691노트

반응식

HRID 1253691 반응식
C(O)(C(F)(F)F)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:31][CH2:30][C:18]3([CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1>C(Cl)Cl>[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:16][CH2:17][C:18]3([CH2:22][NH:21][CH2:20][CH2:19]3)[CH2:30][CH2:31]2)=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 66701232Tert-butyl 8-(4-fluorophenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate

생성물 1

HCID 595056788-(4-Fluorophenyl)-2,8-diazaspiro[4.5]decane

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

TFA (0.6 ml) was added to a cooled (0° C.) solution of tert-butyl 8-(4-fluorophenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.31 mmol, 1.0 eq.) in methylene chloride (2 ml) and the reaction mixture was stirred at 25° C. for 1 h. When the reaction was complete, the solvent was removed in vacuo in order to obtain the desired amine (AMN-22).

후처리

  1. customthe solvent was removed in vacuo in order

출처 및 근거

ORD 기록
ord-8579a9116d994918b771f70eb9441161
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455475B2

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