Trifluoroacetic acid → 2,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

HRID 1253750노트

반응식

HRID 1253750 반응식
C(O)(C(F)(F)F)=O.[F:8][C:9]([F:30])([F:29])[C:10]([N:12]1[CH2:28][CH2:27][C:15]2([CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][CH2:13]1)=[O:11]>>[F:30][C:9]([F:8])([F:29])[C:10]([N:12]1[CH2:28][CH2:27][C:15]2([CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13]1)=[O:11]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 59505224Tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate

생성물 1

HCID 595052392,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

실험 절차

TFA (1 ml) was added to a stirred solution of tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (840 mg, 2.5 mmol) in MC (4 ml) and the mixture was stirred at RT for 12 h. The reaction mixture was then concentrated under reduced pressure and azeotroped with MC (2×10 ml). The crude product was dried and used for the next step without further purification.

후처리

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customazeotroped with MC (2×10 ml)
  3. dry with materialThe crude product was dried
  4. customused for the next step without further purification

출처 및 근거

ORD 기록
ord-6793d3e5bd36422d9e469b9ee9667c7c
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455475B2

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