Potassium Hydroxide → N-(6-(2,8-Diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)-2-chlorobenzamide

HRID 1253752노트

반응식

HRID 1253752 반응식
[OH-].[K+].[Cl:3][C:4]1[CH:39]=[CH:38][CH:37]=[CH:36][C:5]=1[C:6]([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]([N:20]3[CH2:24][CH2:23][C:22]4([CH2:29][CH2:28][N:27](C(=O)C(F)(F)F)[CH2:26][CH2:25]4)[CH2:21]3)=[O:19])[CH:16]=2)[CH2:11][CH2:10]1)=[O:7]>CO>[CH2:21]1[C:22]2([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:23][CH2:24][N:20]1[C:18]([C:15]1[CH:16]=[C:17]2[C:12]([CH2:11][CH2:10][CH:9]2[NH:8][C:6](=[O:7])[C:5]2[CH:36]=[CH:37][CH:38]=[CH:39][C:4]=2[Cl:3])=[CH:13][CH:14]=1)=[O:19]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 595057192-Chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide

생성물 1

HCID 59505509N-(6-(2,8-Diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)-2-chlorobenzamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2 M KOH solution (4 ml) was added to a stirred solution of 2-chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide (200 mg, 0.374 mmol, 1 eq.) in MeOH (4 ml) and the mixture was stirred for 5 h. Methanol was removed under reduced pressure and it was diluted with EtOAc (100 ml) and washed with water (10 ml) and brine (20 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to dryness. The crude material was used for the next step without further purification.

후처리

  1. customMethanol was removed under reduced pressure and it
  2. additionwas diluted with EtOAc (100 ml)
  3. washwashed with water (10 ml) and brine (20 ml)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness
  7. customThe crude material was used for the next step without further purification

출처 및 근거

ORD 기록
ord-ae36efb8cde9449898537cc8f0716fb2
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455475B2

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