Pyrimidine-5-carboxylic acid → Pyrimidine-5-carboxylic acid [5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide

HRID 1253784노트

반응식

HRID 1253784 반응식
[CH:1]1([C:6]2[CH:7]=[C:8]([NH2:18])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:19]1[CH:24]=[C:23]([C:25](O)=[O:26])[CH:22]=[N:21][CH:20]=1>>[CH:1]1([C:6]2[CH:7]=[C:8]([NH:18][C:25]([C:23]3[CH:24]=[N:19][CH:20]=[N:21][CH:22]=3)=[O:26])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

3

반응물 2

HCID 78346Pyrimidine-5-carboxylic acidHCID 712941725-Cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

생성물 1

HCID 71509735Pyrimidine-5-carboxylic acid [5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-amide수율 19%

실험 절차

This compound was prepared following the same procedure as described for Example 3 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 1c) (100 mg, 0.38 mmol) and pyrimidine-5-carboxylic acid (41 mg, 0.33 mmol) as starting materials. The title compound (23 mg, 15.7%) was isolated as off white solid; MS (ESI): 367 [M+H]+.

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-4b77839723534c2e814b76fd3fbd3b56
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455501B2

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