Hydrogen Peroxide → 5-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

HRID 1253792

반응식

HRID 1253792 반응식
[OH:1]O.[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]#[N:15]>C(O)C.N>[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]([NH2:15])=[O:1]

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 179603715-Amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile

생성물 1

HCID 117011915-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

시약·촉매·용매 2

HCID 222Ammonia용매HCID 702Ethanol용매

실험 절차

85 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile (6.74 g, 38.3 mmol) in a mixture of 300 ml of ethanol and 371 ml of concentrated aqueous ammonia solution at room temperature and stirred at room temperature overnight. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solid from the remaining mixture and is filtered off with suction, washed with diethyl ether and dried under high vacuum.

후처리

  1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
  2. customThe product precipitates as solid from the remaining mixture
  3. filtrationis filtered off with suction
  4. washwashed with diethyl ether
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-2c25040e8f5148d7bd8dac74c9d9ebc7
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455502B2

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