Triethylamine → 2-bromo-N-(4-bromo-2,6-dimethylphenyl)propionamide

HRID 1253827노트

반응식

HRID 1253827 반응식
[Br:1][C:2]1[CH:8]=[C:7]([CH3:9])[C:5]([NH2:6])=[C:4]([CH3:10])[CH:3]=1.C(N(CC)CC)C.[Br:18][CH:19]([CH3:23])[C:20](Br)=[O:21].C(=O)([O-])O.[Na+]>O1CCCC1>[Br:18][CH:19]([CH3:23])[C:20]([NH:6][C:5]1[C:7]([CH3:9])=[CH:8][C:2]([Br:1])=[CH:3][C:4]=1[CH3:10])=[O:21]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 79047Propanoyl bromide, 2-bromo-HCID 905494-Bromo-2,6-xylidineHCID 516892Sodium Bicarbonate

생성물 1

HCID 600353552-bromo-N-(4-bromo-2,6-dimethylphenyl)propionamide수율 90.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-bromo-2,6-dimethylaniline (100.0 g) in tetrahydrofuran (400 mL) was added triethylamine (60.7 g) and 2-bromopropionyl bromide (129.5 g) under ice-cooling. The mixture was stirred at room temperature for 1 hour and cooled in an ice-cooling bath. To the reaction mixture was added a sodium hydrogencarbonate aqueous solution and the mixture was stirred at room temperature for 30 minutes. The precipitate was collected by filtration, washed with water and diethyl ether, and dried to give 2-bromo-N-(4-bromo-2,6-dimethylphenyl)propionamide (151.2 g).

후처리

  1. temperaturecooling
  2. temperaturecooling bath
  3. stirringthe mixture was stirred at room temperature for 30 minutes
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with water and diethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-21ed26b6a8294e968cfc271412bfa216
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455511B2

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