4-Toluenesulfonyl chloride → 4H-Thieno[2,3-c]furan-6-one
반응식
O[CH2:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([OH:10])=[O:9].C1(C)C=CC(S(Cl)(=O)=O)=CC=1>ClCCl>[S:5]1[C:4]2[C:8](=[O:9])[O:10][CH2:2][C:3]=2[CH:7]=[CH:6]1참가 물질
4
실험 절차
A solution of 3-hydroxymethyl-thiophene-2-carboxylic acid (25 mg, 0.15 mmol) in dichloromethane (4 ml) and triethylamide (1.5 mL) is treated with p-toluenesulfonyl chloride (50 mg, 0.26 mmol) and the reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the product is purified by chromatography (silica gel, ethylacetate/hexane) to give the title compound. This material was used directly in the preparation of Example 70.
후처리
- concentrationThe reaction mixture is concentrated
- customthe product is purified by chromatography (silica gel, ethylacetate/hexane)
출처 및 근거
- ORD 기록
- ord-4656d918e5db44528d2643027bb0f2b0
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08455535B2
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