Cesium carbonate → 1-(2-(Trimethylsilyl)ethanesulfonyl)-3-((3-methoxypropoxy)(2-(2-cyclohexylethyl)phenyl)methyl)piperidine

HRID 1254199

반응식

HRID 1254199 반응식
[CH:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)=[CH2:2].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:15][Si:16]([CH3:43])([CH3:42])[CH2:17][CH2:18][S:19]([N:22]1[CH2:27][CH2:26][CH2:25][CH:24]([CH:28]([O:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2Br)[CH2:23]1)(=[O:21])=[O:20]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O1CCOCC1>[CH3:15][Si:16]([CH3:43])([CH3:42])[CH2:17][CH2:18][S:19]([N:22]1[CH2:27][CH2:26][CH2:25][CH:24]([CH:28]([O:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[CH2:2][CH2:1][CH:3]2[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:23]1)(=[O:21])=[O:20]

참가 물질

6

반응물 3

HCID 10796Cesium carbonateHCID 12757VinylcyclohexaneHCID 59382843HCID 59382843, 화합물

생성물 1

HCID 593829951-(2-(Trimethylsilyl)ethanesulfonyl)-3-((3-methoxypropoxy)(2-(2-cyclohexylethyl)phenyl)methyl)piperidine수율 82%

시약·촉매·용매 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)촉매HCID 312751,4-Dioxane용매

실험 절차

A sealed tube designed for a microwave reactor was filled with nitrogen and charged with vinylcyclohexane (66 mg, 0.595 mmol, 5.0 equiv) 9-BBN (0.5 M solution in THF, 1.07 mL, 4.5 equiv) and the clear solution was stirred overnight at rt. The flask was briefly opened and Cs2CO3 (213 mg, 0.119 mmol, 3.3 equiv), PdCl2(dppf) (11 mg, 0.119 mmol, 0.05 equiv), 1-(2-(trimethylsilyl)ethanesulfonyl)-3-((3-methoxypropoxy)(2-bromophenyl)methyl)-piperidine (100 mg, 0.197 mmol, 1.0 equiv), and dioxane (4 mL) added. The tube was degassed by three evacuate/N2 backfill cycles, then placed in a CEM microwave reactor and heated to 120° C. for 10 min. The solvent was removed and the product was extracted with EtOAc and filtered through a pad of Celite. The product was purified by flash chromatography on 12 g of silica, eluting with 0 to 27% EtOAc in hexanes, to afford 1-(2-(trimethylsilyl)ethanesulfonyl)-3-((3-methoxypropoxy)(2-(2-cyclohexylethyl)phenyl)methyl)piperidine (82%) as a mixture of diastereomers. 1H NMR (CDCl3) δ 0.02 (s, 9H), 0.8-1.9 (m, 24H), 2.5-2.8 (m, 4H), 3.3-4.4 (m, 11H), 7.1-7.3 (m, 4H). MS ESI +ve m/z 561 (M+Na+).

후처리

  1. customA sealed tube designed for a microwave reactor
  2. additionwas filled with nitrogen
  3. customThe tube was degassed by three
  4. customevacuate/N2 backfill cycles
  5. temperatureheated to 120° C. for 10 min
  6. customThe solvent was removed
  7. extractionthe product was extracted with EtOAc
  8. filtrationfiltered through a pad of Celite
  9. customThe product was purified by flash chromatography on 12 g of silica
  10. washeluting with 0 to 27% EtOAc in hexanes

출처 및 근거

ORD 기록
ord-6a880111eb96489c85fcc14ca3da3b74
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455521B2

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