Picolinate → Methyl 5-(4-ethylphenyl)-6-(pyridin-2-yl)pyridine-2-carboxylate

HRID 12543

반응식

HRID 12543 반응식
N1C=CC=CC=1C([O-])=O.[CH2:10]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=3)=[N:20][C:21]([C:24]([O:26][CH2:27]C)=[O:25])=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH3:11]>OS(O)(=O)=O.CO>[CH2:10]([C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([O:26][CH3:27])=[O:25])=[N:20][C:19]=2[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=2)=[CH:16][CH:17]=1)[CH3:11]

참가 물질

5

반응물 2

HCID 6920223PicolinateHCID 68409104Ethyl 3-(4-Ethylphenyl)-[2,2']-bipyridinyl-6-carboxylate

생성물 1

HCID 59338839Methyl 5-(4-ethylphenyl)-6-(pyridin-2-yl)pyridine-2-carboxylate

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 887Methanol용매

실험 절차

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(pyridine-2-yl)phenyl)pyridine-2-carboxylate (Compound 50, 16 mg, 0.05 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-f84eb07691ad48848f4d45b22cacaa43
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728014B2

연결된 노트

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