(S)-N-Cbz-1,1-diethoxypropan-2-amine → (2S)-1,1-Diethoxy-2-propanamine

HRID 1254487노트

반응식

HRID 1254487 반응식
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH:7]C(=O)OCC1C=CC=CC=1)[CH3:6])[CH3:2]>CO>[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH2:7])[CH3:6])[CH3:2]

참가 물질

3

반응물 1

HCID 86652567(S)-N-Cbz-1,1-diethoxypropan-2-amine

생성물 1

HCID 12398111(2S)-1,1-Diethoxy-2-propanamine수율 100.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To the solution of (S)-benzyl 1,1-diethoxypropan-2-ylcarbamate 844 mg (3.00 mmol) in methanol 50 ml, 5% palladium on carbon 30 mg was added and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered on celite and washed with methanol 200 ml and the mother solution was concentrated in vacuo to obtain the title compound 442 mg (100%).

후처리

  1. filtrationThe reaction mixture was filtered on celite
  2. washwashed with methanol 200 ml
  3. concentrationthe mother solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-75d9869761dd4da4a9e78290eb8f57e3
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455488B2

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