Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → 2-chloro-N-(isoquinolin-6-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | 6-Aminoisoquinoline | HCID 588991 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-chloro-N-(isoquinolin-6-yl)acetamide | HCID 24999501 | — |
반응 단계
To chloroacetic acid in DMF was added EDC, DMAP and 6-aminoisoquinoline. This mixture was stirred for 4 hours. The reaction was washed with NaHCO3(sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, 5% MeOH/CH2Cl2) gave 2-chloro-N-(isoquinolin-6-yl)acetamide (E1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08455647B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-52c587bdd6a840ed90e7270b93d24eb8 |
| 출처 메모 | uspto-grants-2013_06 |