4-Fluorobenzaldehyde → 1-(Bromomethyl)-4-(propane-2-sulfonyl)benzene

HRID 1254904노트

반응식

HRID 1254904 반응식
[Br:1]CC1C=CC(S(C)(=O)=O)=C(F)C=1.F[C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1.[Na+].[CH3:24][CH:25]([S:27]([O-:29])=[O:28])[CH3:26]>>[Br:1][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([S:27]([CH:25]([CH3:26])[CH3:24])(=[O:29])=[O:28])=[CH:16][CH:17]=1

참가 물질

4

반응물 3

HCID 680234-FluorobenzaldehydeHCID 23685748Sodium propane-2-sulfinateHCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

생성물 1

HCID 672197581-(Bromomethyl)-4-(propane-2-sulfonyl)benzene

실험 절차

The titled compound is prepared analogously to 4-bromomethyl-2-fluoro-1-methanesulfonyl-benzene by replacing 3,4-difluorobenzaldehyde with 4-fluorobenzaldehyde and by replacing methane sulfinic acid sodium salt with 2-propane sulfinic acid sodium salt.

출처 및 근거

ORD 기록
ord-b91346c6c69243ba8eb3a86a20537c7d
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455645B2

반응 노트

불러오는 중…