Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-(5-bromo-4-methylthiazol-2-yl)-2,6-difluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| 반응물 | 5-Bromo-4-(trifluoromethyl)-1,3-thiazol-2-amine | HCID 15710701 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(5-bromo-4-methylthiazol-2-yl)-2,6-difluorobenzamide | HCID 59004504 | 83% |
반응 단계
2-Amino-5-bromo-4-trifluoromethylthiazole (0.8 g) was dissolved in 3 mL of 1:1 mixture of THF and pyridine. 2,6-difluorobenzoylchloride (0.6 g) was added at room temperature with stirring. The mixture was stirred for 3 hours at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure. Flash chromatography on silica gel gave the title compound as a white solid. Yield 83%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08455658B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-4b25ee29242644d2a6e5c548bebbf70c |
| 출처 메모 | uspto-grants-2013_06 |