Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(5-(7-Bromobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide → N-(5-(Benzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(5-(7-Bromobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide | HCID 24765405 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-(5-(Benzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide | HCID 24765406 | 89.6% |
반응 단계
A mixture of Compound 56 (50 mg) and 10% Pd/C (10 mg) in EtOH (2.0 mL) was stirred under an atmosphere of hydrogen gas overnight. The mixture was filtered through a short plug of celite. The filtrate was concentrated under reduced pressure to give Compound 57 (37 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08455658B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-1633d1f55bc040fe830af7ca214998b6 |
| 출처 메모 | uspto-grants-2013_06 |