5-(Carboxymethyl)-2-chlorobenzoic acid → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

HRID 1255242

반응식

HRID 1255242 반응식
[C:1]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([Cl:14])=[C:9]([CH:13]=1)[C:10](O)=[O:11])(O)=[O:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:14][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:1][OH:2])=[CH:13][C:9]=1[CH:10]=[O:11]

참가 물질

4

반응물 1

HCID 579893705-(Carboxymethyl)-2-chlorobenzoic acid2회

생성물 1

HCID 579893312-Chloro-5-(2-hydroxyethyl)benzaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol [Aromatic Intermediate 7, step c] (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

후처리

  1. filtrationThe mixture was then filtered through Celite
  2. washwashing the residue well with DCM
  3. concentrationThe filtrate and washings were concentrated in vacuo

출처 및 근거

ORD 기록
ord-e5b402bbde5f48b0ae84dbe57e5b46c6
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08455483B2

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