Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Methyl (2E)-3-(3-nitrophenyl)-2-propenoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 반응물 | Trimethyl phosphonoacetate | HCID 80029 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl (2E)-3-(3-nitrophenyl)-2-propenoate | HCID 5354136 | 98% |
반응 단계
To a solution of 3-nitro-benzaldehyde (15 g, 0.1 mol), (dimethoxy-phosphoryl)-acetic acid methyl ester (27 g, 0.148 mol) in DMF (100 ml) was added NaOMe (10.7 g 0.198 mol). The reaction was monitored by TLC. After reaction was completed, the reaction mixture was adjusted to pH=1 with aqueous HCl solution and evaporated. The resulting solid was washed with water to afford (E)-methyl 3-(3-nitrophenyl)acrylate as a yellow solid (20.14 g, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08461157B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-faa260799f1e4e92b1806c51c06131dd |
| 출처 메모 | uspto-grants-2013_06 |