Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrazine hydrate (1:1) → N4-Phenylquinazoline-4,6-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 6-Nitro-N-phenylquinazolin-4-amine | HCID 5328189 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Water ethanol | HCID 19096565 | — |
| 생성물 | N4-Phenylquinazoline-4,6-diamine | HCID 5328187 | — |
반응 단계
A solution of a 6-nitro-4-(phenylamino)quinazoline substituted by a polyalkylene glycol derivative terminating with a fifth reactive group, prepared as described hereinabove, in ethanol/water is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel (Ra—Ni). The reaction mixture is filtered and evaporated, to give the corresponding 6-amino-4-(phenylamino)quinazoline substituted by a polyalkylene glycol moiety terminating with a reactive group.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08461166B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-cb036731962c42c7a75e6196a3c6d492 |
| 출처 메모 | uspto-grants-2013_06 |