Chlorosulfonic acid → 1-(Trifluoroacetyl)-2,3-dihydro-1H-indole-5-sulfonyl chloride

반응식

[F:1][C:2]([F:15])([F:14])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)=[O:4].[Cl:16][S:17](O)(=[O:19])=[O:18]>>[F:15][C:2]([F:1])([F:14])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([S:17]([Cl:16])(=[O:19])=[O:18])=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)=[O:4]

참가 물질

반응물 2

HCID 24638Chlorosulfonic acid

HCID 44055422,2,2-Trifluoro-1-indolinylethan-1-one

생성물 1

HCID 110883061-(Trifluoroacetyl)-2,3-dihydro-1H-indole-5-sulfonyl chloride

실험 절차

2,2,2-trifluoro-1-(indolin-1-yl)ethanone (5 g, 16 mmol) was added to neat chlorosulfonic acid at 0° C. and then the solution was allowed to warm to rt and stirred for an additional 2 hrs. Reaction mixture was slowly added to ice chips and stirred for 10 min then filtered off 4.2 g of the title compound as a dark red colored solid.

후처리

customReaction mixture
additionwas slowly added to ice chips
stirringstirred for 10 min
filtrationthen filtered off 4.2 g of the title compound as a dark red colored solid

출처 및 근거

ORD 기록: ord-6905320e0f504b3b9d75917496af3bf9
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08461134B2

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