Nitric Acid → N-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine
반응식
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][N:4]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>O>[CH3:1][NH:2][C:3]1[C:8]([N+:18]([O-:20])=[O:19])=[CH:7][C:6]([C:9]([F:12])([F:10])[F:11])=[CH:5][N:4]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
Into a mixture of 17.3 g of N-methyl(5-trifluoromethylpyridin-2-yl)-amine and 100 ml of sulfuric acid was dropped 12.3 g of nitric acid, then, the mixture was stirred for 2 hours while heating at 80° C. After cooling down to room temperature, water was poured into the reaction mixture, and the deposited precipitate was filtrated, then, washed with water, then, dried under reduced pressure to obtain 18.8 g of N-methyl(3-nitro-5-trifluoromethylpyridin-2-yl)-amine.
후처리
- temperatureAfter cooling down to room temperature
- filtrationthe deposited precipitate was filtrated
- washwashed with water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-5847bb67d5674dbbbe148653720d92df
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08461181B2
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