Tert-Butylamine → N-tert-butyl-2-nitro-4-(trifluoromethyl)aniline

HRID 1256622노트

반응식

HRID 1256622 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CN1CCCC1=O.[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>O>[C:22]([NH:26][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])([CH3:25])([CH3:24])[CH3:23]

참가 물질

5

반응물 3

HCID 6385Tert-ButylamineHCID 13387N-methyl-2-pyrrolidoneHCID 677784-Fluoro-3-nitrobenzotrifluoride

생성물 1

HCID 2736447N-tert-butyl-2-nitro-4-(trifluoromethyl)aniline수율 81.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 5.22 g of 4-fluoro-3-nitro-benzo trifluoride and 25 ml of N-methylpyrrolidone was added 3.88 g of tert-butylamine, and the mixture was stirred for 2 hours at room temperature. The reaction mixture was poured into water, the deposited solid was collected by filtration. This solid was washed with water, then, dried under reduced pressure, to obtain 5.35 g of N-tert-butyl-2-nitro-4-trifluoromethylaniline.

후처리

  1. filtrationthe deposited solid was collected by filtration
  2. washThis solid was washed with water
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5b34e1fa7dc04e48989dd2b8aea57fee
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461181B2

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