Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Metformin Hydrochloride → 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Metformin Hydrochloride | HCID 14219 | — |
| 반응물 | Paraldehyde | HCID 31264 | — |
| 촉매 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 용매 | Isobutanol | HCID 6560 | — |
| 생성물 | 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1) | HCID 10176486 | 183.1% |
반응 단계
A mixture of 1002.6 g of metformin hydrochloride, 359.1 g of paraldehyde and 51.6 g of toluene-4-sulfonic acid monohydrate in 2405.9 g of isobutanol is heated under reflux for 6 hours. Some of the solvent is removed by distillation. The mixture is cooled to 12°, and the white precipitate is separated off, giving 953.8 g (81.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08461331B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-76c475bd77424e0dbfe513292e2657e1 |
| 출처 메모 | uspto-grants-2013_06 |