Acetyl chloride → Tert-butyl 4-acetylpiperazine-1-carboxylate
반응식
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(N(CC)CC)C.[C:21](Cl)(=[O:23])[CH3:22]>ClCCl>[C:21]([N:11]1[CH2:10][CH2:9][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:13][CH2:12]1)(=[O:23])[CH3:22]참가 물질
5
실험 절차
A solution of N-Boc-piperazine (300 mg, 1.63 mmol), triethylamine (494 mg, 3 equiv), and acetyl chloride (1.5 equiv) in dichloromethane was stirred overnight at rt. The solution was quenched by the dropwise addition of water. The organic layer was separated, dried over anhydrous Na2SO4, and evaporated in vacuo. The residue was purified by flash chromatography to give the title compound (˜85% yield) as a solid.
후처리
- customThe solution was quenched by the dropwise addition of water
- customThe organic layer was separated
- dry with materialdried over anhydrous Na2SO4
- customevaporated in vacuo
- customThe residue was purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-17373938cac64b8cac4b38ed704fe09c
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08461339B2
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