Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Acetylpiperazine | HCID 83795 | — |
| 반응물 | 2-Chloro-4-(chloromethyl)pyridine | HCID 11126573 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine | HCID 58285182 | — |
반응 단계
N-Acetylpiperazine (1.0 equiv) was mixed with compound 2-chloro-4-(chloro-methyl)pyridine (1.0 equiv) and K2CO3 (4 equiv) in DMF. The mixture was stirred for 1 h at rt. After removing most of the solvent, the residue was partitioned in water and EtOAc. The organic layer was separated, dried over anhydrous Na2SO4, and evaporated in vacuo. The residue was purified by flash chromatography to give the title compound as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08461339B2 |
| 출처 데이터셋 | uspto-grants-2013_06 |
| ORD ID | ord-99434ad2b24e4ade9640c921364c5de3 |
| 출처 메모 | uspto-grants-2013_06 |