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3-(Trifluoromethyl)benzaldehyde → (2E)-3-(3-(trifluoromethyl)phenyl)prop-2-enal

HRID 1257304
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반응식

HRID 1257304 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.C1(P(=[CH:32][CH:33]=[O:34])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5](/[CH:6]=[CH:32]/[CH:33]=[O:34])[CH:8]=[CH:9][CH:10]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 75051(Triphenylphosphoranylidene)acetaldehyde

생성물 1

HCID 10488238(2E)-3-(3-(trifluoromethyl)phenyl)prop-2-enal수율 51.1%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

3-(Trifluoromethyl)benzaldehyde (0.70 g) was dissolved in toluene (16 mL), and (triphenylphosphoranylidene)acetoaldehyde (1.22 g) was added. The reaction mixture was heated under reflux for 40 hr and concentrated, and the residue was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate) to give the title compound (0.41 g) as an oil.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 40 hr
  3. concentrationconcentrated
  4. customthe residue was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-cd80c6a0bba347869be0533b44a11e18
출처 데이터셋
uspto-grants-2013_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08461348B2

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