ethyl 1-(2-tert-butoxy-2-oxoethyl)-1H-pyrazole-4-carboxylate → [4-(ethoxycarbonyl)-1H-pyrazol-1-yl]acetic acid
반응식
C([O:5][C:6](=[O:18])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:10]=[N:9]1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:16]([O:15][C:13]([C:11]1[CH:10]=[N:9][N:8]([CH2:7][C:6]([OH:18])=[O:5])[CH:12]=1)=[O:14])[CH3:17]참가 물질
3
실험 절차
The compound (17.5 g) obtained in Example 115a was added to trifluoroacetic acid (280 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was washed with hexane, and dried to give the title compound (15.0 g) as a colorless solid.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- washthe residue was washed with hexane
- customdried
출처 및 근거
- ORD 기록
- ord-09e4e0fb3f704497bab09c9b872ea197
- 출처 데이터셋
- uspto-grants-2013_06
- 특허 번호
- US08461348B2
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