Oxalyl chloride → Methyl 4-(2-chloro-2-oxoethyl)benzoate

HRID 1257474노트

반응식

HRID 1257474 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)=[O:4].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[Cl:18][C:12](=[O:14])[CH2:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 107978792-(4-(Methoxycarbonyl)phenyl)acetic acid

생성물 1

HCID 19746402Methyl 4-(2-chloro-2-oxoethyl)benzoate

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of the compound (3.0 g) obtained in Example 206a in dichloromethane (50 mL) was cooled in an ice bath, and oxalyl chloride (3.93 g) and N,N-dimethylformamide (2 drops) were added. The reaction mixture was stirred at room temperature overnight, and the solvent was evaporated under reduced pressure to give the title compound.

후처리

  1. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f6db7af0968d4d169df79cf7eee4e942
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461348B2

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