Water → 5-(3-(Trifluoromethyl)phenyl)furfural

HRID 1257477

반응식

HRID 1257477 반응식
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([CH2:14][OH:15])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.O>ClCCl>[F:16][C:2]([F:1])([F:17])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([CH:14]=[O:15])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 159087TriacetoxyperiodinaneHCID 7782745{5-[3-(trifluoromethyl)phenyl]furan-2-yl}methanol

생성물 1

HCID 7218375-(3-(Trifluoromethyl)phenyl)furfural

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of the compound (0.45 g) obtained in Example 130b in dichloromethane (4 mL) was cooled in an ice bath, and Dess-martin reagent (0.94 g) was added. After stirring at room temperature for 1 hr, water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was washed with saturated aqueous sodium thiosulfate solution, dried over magnesium sulfate, and concentrated under reduced pressure to give a crude title compound.

후처리

  1. extractionthe mixture was extracted with dichloromethane
  2. washThe organic layer was washed with saturated aqueous sodium thiosulfate solution
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c14da28565a44c74a7cdb7c0a1816852
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461348B2

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