1-Pentanol → 2-(4-Fluorophenyl)-7-(4-methoxybenzyl)imidazo[1,2-b][1,2,4]triazine

HRID 1257769노트

반응식

HRID 1257769 반응식
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][CH:10]=2)=[CH:5][CH:4]=1.Cl[CH:17]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[CH:18]=O.C(O)CCCC>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][C:12]3[N:13]([C:17]([CH2:20][C:21]4[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=4)=[CH:18][N:15]=3)[N:14]=2)=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 62761-PentanolHCID 121027562-Chloro-3-(4-methoxyphenyl)propanalHCID 672240866-(4-Fluorophenyl)-1,2,4-triazin-3-amine hydrochloride

생성물 1

HCID 248018432-(4-Fluorophenyl)-7-(4-methoxybenzyl)imidazo[1,2-b][1,2,4]triazine

반응 조건

온도
130 °C

실험 절차

A mixture of 6-(4-fluorophenyl)-1,2,4-triazin-3-amine hydrochloride (50 mg, 0.2 mmol) and 2-chloro-3-(4-methoxyphenyl)propanal (48 mg, 0.24 mmol) in tent-amyl alcohol (1 mL) was heated at 130° C. for 4 h. After cooling, the mixture was purified by preparative HPLC to afford the desired product. (7.1 mg) LCMS: (M+H)=335.1.

후처리

  1. temperatureAfter cooling
  2. customthe mixture was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-616f148b72034667bd06323fcd77cb21
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08461330B2

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