Lamotrigine → 2-(2,3-Dichlorophenyl)-7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-3-amine

참여 물질

역할	이름	HCID	투입량
반응물	Lamotrigine	HCID 3878	—
반응물	Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde	HCID 86621504	—
용매	Ethanol	HCID 702	—
생성물	2-(2,3-Dichlorophenyl)-7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-3-amine	HCID 59420986	35.3%

반응 조건

온도	105 °C

반응 단계

A mixture of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (19 mg, 0.076 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (22 mg, 0.091 mmol) in ethanol (0.50 mL) was stirred at 105° C. overnight. The reaction mixture was purified by RP-HPLC (pH 10) to afford the desired product (12 mg, 35%). LCMS: (M+H)=447.3/449.2/451.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08461330B2
출처 데이터셋	uspto-grants-2013_06
ORD ID	ord-ff8d1570be5f45e5a4b5f2bad08afa2b
출처 메모	uspto-grants-2013_06