Acetic Acid → Dimethyl-(6-trifluoromethyl-1H-indol-5-yl)amine

HRID 1258205노트

반응식

HRID 1258205 반응식
[CH3:1][N:2]([CH3:19])[C:3]1[C:4]([C:15]([F:18])([F:17])[F:16])=[CH:5][C:6]([N+:12]([O-])=O)=[C:7]([CH2:9][C:10]#N)[CH:8]=1.C(O)C.C(O)(=O)C>[C].[Pd].O>[CH3:1][N:2]([CH3:19])[C:3]1[CH:8]=[C:7]2[C:6](=[CH:5][C:4]=1[C:15]([F:18])([F:17])[F:16])[NH:12][CH:10]=[CH:9]2

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 702EthanolHCID 58437521(5-Dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile

생성물 1

HCID 58437283Dimethyl-(6-trifluoromethyl-1H-indol-5-yl)amine수율 119.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 962Water용매

반응 조건

온도
35 °C

실험 절차

To a solution of (5-dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile (0.058 g) in a mixed solvent of ethanol (1 mL), acetic acid (0.1 mL) and water (0.1 mL) was added palladium-carbon powder (0.0058 g), and this mixture was stirred at 35° C. for 16 hours. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (0.058 g).

후처리

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-226364abaa3d46a59ba675898bf532c5
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466152B2

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