Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1258211생성일: 2026년 10월 26일
Water → 4-[6-(2-Benzyloxycarbonylaminoethyloxy)-3-cyanoindol-1-yl]-2-methoxymethoxy-benzoic acid ethyl ester
https://huagongshe.com/reaction/1258211
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | benzyl N-(2-bromoethyl)carbamate | HCID 278694 | — |
| 반응물 | 4-(3-Cyano-6-hydroxyindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester | HCID 58437526 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[6-(2-Benzyloxycarbonylaminoethyloxy)-3-cyanoindol-1-yl]-2-methoxymethoxy-benzoic acid ethyl ester | HCID 58437239 | 72.9% |
반응 단계
To a solution of 4-(3-cyano-6-hydroxyindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester (0.37 g) in N,N-dimethylformamide (10 mL) were added (2-bromoethyl)carbamic acid benzyl ester (0.39 g) and potassium carbonate (0.28 g), and this mixture was stirred at 50° C. overnight. This reaction mixture was poured into water, and the precipitated solid was collected by filtration. This solid was washed with methanol, and dried to give the title compound (0.40 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08466152B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_06 |
|---|
| ORD ID | ord-5f6ed8e64ad847c2ae2533b7e92a129c |
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| 출처 메모 | uspto-grants-2013_06 |
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