Ethanol → 5-(4-Methoxyphenyl)-2,2-dimethylfuran-3(2H)-one

HRID 1258262노트

반응식

HRID 1258262 반응식
O[C:2]([CH3:16])([CH3:15])[C:3]#[C:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=[O:6].CC[OH:19]>>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[O:6][C:2]([CH3:16])([CH3:15])[C:3](=[O:19])[CH:4]=2)=[CH:8][CH:9]=1

참가 물질

3

반응물 2

HCID 702Ethanol2회HCID 127225774-Hydroxy-1-(4-methoxyphenyl)-4-methylpent-2-yn-1-one

생성물 1

HCID 145333195-(4-Methoxyphenyl)-2,2-dimethylfuran-3(2H)-one수율 92%

실험 절차

To a stirred solution of 4-hydroxy-1-(4-methoxyphenyl)-4-methylpent-2-yn-1-one (6 g, 0.027 mol) in ethanol (100 mL) diethyl amine (2.86 g, 0.027 mol) in EtOH (15 mL) was added dropwise at RT and the reaction mixture was stirred for additional 4 h. The EtOH was then removed and the mixture diluted with EtOAc (100 mL). The combined organic layers were washed with water (50 mL) and brine (20 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford 5-(4-methoxyphenyl)-2,2-dimethylfuran-3(2H)-one (5.5 g, 92%).

후처리

  1. customThe EtOH was then removed
  2. additionthe mixture diluted with EtOAc (100 mL)
  3. washThe combined organic layers were washed with water (50 mL) and brine (20 mL)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-ddf52f3a9f6a4d40a40190126d6c82ab
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466148B2

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