Iodine → N-(3-iodo-4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide

반응식

Br[C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[C:5]2[C:10]([C:11]=1[OH:12])=[CH:9][CH:8]=[CH:7][CH:6]=2.[I:22]I>>[I:22][C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[C:5]2[C:10]([C:11]=1[OH:12])=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

반응물 2

HCID 807Iodine

HCID 7718544N-(3-bromo-4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide

생성물 1

HCID 46909346N-(3-iodo-4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide수율 100%

실험 절차

was prepared according to the procedure for 4b except using I2 solid. The reaction afforded title compound 129.4 mg (100%) as a brown solid, m.p.: 134-136° C.

후처리

customwas prepared

출처 및 근거

ORD 기록: ord-3cc4bb9da5e3467d9f9aac187c045266
출처 데이터셋: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08466157B2

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